The International Sweeteners Association (ISA) is rebutting recent research suggesting that sucralose affects brain appetite regulation. The association underscores that low- and no-calorie sweeteners like sucralose are important tools for sugar and calorie reduction, as obesity and diet-related non-communicable diseases like diabetes are a growing challenge. Last month, researchers found that sucralose increased activity in the hypothalamus, an appetite-regulating brain region, whereas sugar did not.